XPRESSO: automation in routine crystallography
نویسندگان
چکیده
منابع مشابه
Automation of sample mounting for macromolecular crystallography.
A standard sample holder and vial for cryocooled macromolecular crystals has been defined for use with robotic sample changers. This SPINE standard sample holder is a modified version, with added features and specifications, of sample holders in common use. In particular, the SPINE standard meets the precision required for automatic sample exchange and includes a cap that is identified by a two...
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Quantitative assays of all sorts are common to many applications in basic science and clinical research. Most of these assays require the movement, either addition or subtraction, of liquid reagents. Historically these assays were performed in test tubes. However, regardless of the assay method employed, laboratories requiring high throughput have often adapted the described protocol to a 96-we...
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1. Define the principles of gel and solid-phase technology. 2. Describe the test reactions and methods of grading reactions for each technology. 3. List the advantages and disadvantages of each technology. 4. Compare the two technologies in terms of equipment, test reactions, procedures, sensitivity, and quality control. 5. Discuss the automated equipment that is available for each technology. ...
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INTRODUCTION The investigation of platelet function by aggregometry requires specialist equipment and is labour intensive. We have developed an automated platelet aggregation method on a routine coagulation analyser. METHODS We used a CS-2000i (Sysmex) with prototype software to perform aggregation in platelet-rich plasma (PRP), using the following agonists: ADP (0.5-10 μm), epinephrine (0.5-...
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The sulfur SAD phasing method allows the determination of protein structures de novo without reference to derivatives such as Se-methionine. The feasibility for routine automated sulfur SAD phasing using a number of current protein crystallography beamlines at several synchrotrons was examined using crystals of trimeric Achromobacter cycloclastes nitrite reductase (AcNiR), which contains a near...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2010
ISSN: 0108-7673
DOI: 10.1107/s0108767310097667